Arsenal welcome Olympiacos to the Emirates Stadium for the second leg of the Europa League last 16 tie tonight.
The Gunners won 3-1 in the reverse fixture, but they were lucky as the Greek outfit failed to capitalise on some defensive errors.
Bernd Leno is the first-choice goalkeeper and he is expected to start.
The backline could see a solitary change at right-back.
Thomas Partey looked jaded in the final 15 minutes of the derby, which saw him make several fouls.
Dani Ceballos is another option available, but the Spaniard has been poor with his recent European displays.
Bukayo Saka was nursing a hamstring issue, but he is likely to be deemed fit for the game.
Aubameyang was left on the bench for the derby after arriving late and breaking the pre-match protocols.
Lacazette did score the winning penalty against Spurs, but he squandered few clear-cut chances prior to that.
Hence, the club-captain should lead the line ahead of the Frenchman.