In the defence, there could be a few changes. Luke Shaw has been the preferred choice at left-back for the league games and should start ahead of Alex Telles.
Victor Lindelof is likewise expected to return to the starting XI. Eric Bailly returned after his injury absence in midweek but he should make way for the Swede to partner Harry Maguire in the central defence.
Scott McTominay and Fred have been the regular midfield choices for Solskjaer in the absence of Paul Pogba due to a thigh injury. McTominay is an injury doubt and that may see Nemanja Matic earn his first start in five league games.
Further forward, there could be a solitary change with Anthony Martial returning to the starting line-up. The Frenchman may lead the line with Edinson Cavani doubtful with a calf problem.